Methodological development for structural studies of RNA by solid-state NMR spectroscopy
We are pioneers in the application of solid-state NMR for the structural studies of RNA. We are working on the development of new experiments, new labeling schemes and new strategies for structural characterization of RNA. Our area of expertise includes solution- and solid-state NMR, EPR and DNP. Newly developed methods will find broad applicability to large RNA and protein-RNA complexes and will open new possiblities for both NMR and structural biology and contribute to the fast growing field of RNA therapeutics
Marchanka et al. Nat. Comm. 2015. 6:7024.
Structural and functional studies of viral and bacterial RNAs
We are investigating desease-related viral and bacterial RNAs by NMR and complementary biophysical techniques (SAXS, SANS) to obtain valuable structural and functional information on the RNA molecule. The availablity of the precise structural information will contribute to the development of new effective drugs.